Literature Review on the Therapeutic Potential of NAMPT in Brain Diseases

Nicotinamide Phosphoribosyl transferase (NAMPT) is an important enzyme in the biosynthesis NAD+ and byproduct nicotinamide mononucleotide (NMN) also a vital intermediate synthesis. More importantly, has been found to have therapeutic potential management treatment of brain diseases such as stroke, depression, cerebral ischemic injury. In this review, we looked critically at studies that sought explore activities NAMPT brain, relevant pathways, byproducts, precursors with hope utilizing knowledge gotten from project possibility better way treat diseases. The projected double-edged influence on cell processes aging Likewise, it neuroprotective advantages neurons express them. scientific shown involved chain preventing depression. This review further elaborates potentials NAMPT, seeks recommend field be carried out regular basis due its promising potential.
 Keywords: NAMPT; Brain; Therapeutic potential; Diseases; NAD; Cerebral injury, Stroke